miércoles, 7 de abril de 2010

Cancer Research—Formaldehyde-Induced Cancers


Cancer Research—Formaldehyde-Induced Cancers

Investigators at the National Center for Toxicological Research (NCTR) and the Hamner Institutes for Health Sciences have used a sensitive molecular method (ACB-PCR) to develop data that suggests the mechanism that causes nasal tumors in formaldehyde-treated rats likely does not involve direct-genetic damage. It has been concluded there is sufficient epidemiologic evidence that formaldehyde causes nasopharayngeal cancer in humans. Regulatory determination of safe levels of formaldehyde utilizes the rodent-cancer data and a mathematical approach based on an understanding of the mechanism of tumor formation. The high-sensitivity and quantitative nature of NCTR's ACB-PCR technology facilitates the assessment of early and rare mutational events associated with tumor formation.

This research coupled with previous studies to assess the biological effects of formaldehyde on the rat nose will provide a scientific basis for selecting the appropriate mathematical model to assess human risk from formaldehyde exposure. A publication describing this research was recently accepted (Regulatory Toxicology and Pharmacology, 2010).

For additional information, please contact Barbara Parsons, Ph.D., Division of Genetic and Reproductive Toxicology, FDA/NCTR.
http://www.fda.gov/AboutFDA/CentersOffices/NCTR/WhatWeDo/NCTRPublications/ucm076767.htm

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