jueves, 15 de abril de 2010

NCTR Research Highlights


Current Highlight from April 9, 2010

HIV Drug Research—Translational Biomarkers

Scientists from the National Center for Toxicological Research (NCTR) and the Technical University of Lisbon have identified a sensitive biomarker of internal exposure to nevirapine in rats. Nevirapine is approved for use in combination therapy of HIV-1 infection. Despite its clinical efficacy, nevirapine administration is associated with a variety of toxic responses including hepatotoxicity, which can be fatal.

While the reason for the adverse effects of nevirapine administration are currently not clear, these studies show that nevirapine is metabolically activated to an intermediate that forms hemoglobin adducts that can be detected by mass spectrometry. The characterization of the hemoglobin-nevirapine adduct provides a relatively noninvasive biomarker of internal exposure to monitor nevirapine toxicity.

For additional information, please contact Fred Beland, Ph.D., Director, Division of Biochemical Toxicology, FDA/NCTR.

NCTR Research Highlights

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